Civil Liberties and Terrorism
Following the May 2017 Manchester terrorist attack, Mr Mann posted a video on YouTube in which he said "Frankly, I don't care who's looking at my internet and social media, if it means they're looking at the terrorists, they're getting early intelligence, they're catching more of them. In that trade-off, I back more powers for the security services and the police at the expense of civil liberties."
In May 2008 in the abortion amendments to the Human Fertilisation and Embryology Bill (now Act), John Mann voted to keep the current time limit of 24 weeks in line with the scientific and medical consensus.
In February 2015 John Mann voted in favour of allowing mitochondrial donation, which would allow women who carried mitochondrial diseases to give birth to children who would not inherit the disease. An October 2014 briefing report by the Human Fertilisation and Embryology Authority (HFEA), which had been investigating the issue for three years, stated that there was no evidence to show that mitochondrial donation was unsafe. However, some religious groups had said that such procedures should not be allowed. After clearing both Houses mitochondrial donation is now legal, regulated by the HFEA.
Protection of the title of Doctor
In June 2009, the John Mann proposed Early Day Motion 1635, a call for the protection of the title of doctor to avoid confusion caused by the use of the term doctor by practitioners of complementary medicine. 
John Mann signed the February 2009 Early Day Motion 754: MMR Vaccine and the Media supporting the use of the MMR vaccine. The motion expressed disappointment with the reporting of the vaccine by Jeni Barnett on her LBC radio show in January 2009, and expressed the hope that future reporting of the issue of MMR would be less sensationalist and more evidence-based.
Libel Law Reform
In February 2010, John Mann signed Early Day Motion 423 calling for a reform of the English libel law. The next month, he transferred his signature to the amended EDM 423A1. The original motion noted that human rights activists, scientists, writers and journalists are currently prevented from publishing, and the public prevented from reading, matters of strong public interest due to the chilling effect of the law. The amended version added a statement of the belief that "libel laws discriminate against average and low paid people when victims of defamatory comment in the pages of national publications".
Mr Mann has published two documents:
- The Real Deal: Drugs Policy that Works (2006) webpage PDF
- What Every Parent and Grandparent Needs to Know about Drugs and Alcohol (2009) PDF
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