Following decisions by the Boundary Commission for England, Knowsley North and Sefton East and Knowsley South were abolished for the 2010 general election to create the new seat of Knowsley. O'Hara was defeated by current MP for Knowsley North and Sefton East George Howarth in the selection for the Labour candidacy, and did not seek re-election to the House.
Edward O'Hara signed the February 2009 Early Day Motion 754: MMR Vaccine and the Media supporting the use of the MMR vaccine. The motion expressed disappointment with the reporting of the vaccine by Jeni Barnett on her LBC radio show in January 2009, and expressed the hope that future reporting of the issue of MMR would be less sensationalist and more evidence-based.
In March 2010, following the publication of the House of Commons Science and Technology Committee's report "Evidence Check 2: Homeopathy", O'Hara signed Early Day Motion 908: Science and Technology Committee Report on Homeopathy, which was critical of the report.
In May 2008 in the abortion amendments to the Human Fertilisation and Embryology Bill (now Act), Edward O'Hara voted to keep the current time limit of 24 weeks in line with the scientific and medical consensus.
Libel Law Reform
In December 2009, Edward O'Hara signed the amended Early Day Motion 423A1 calling for a reform of the English libel law. The motion noted that human rights activists, scientists, writers and journalists are currently prevented from publishing, and the public prevented from reading, matters of strong public interest due to the chilling effect of the law.
The original EDM 423 was tabled following the recent formation of Libel Reform Coalition, which has the backing of Index on Censorship, English PEN and Sense about Science. Sense about Science have been campaigning in defense of a member of its board of trustees, author and journalist Simon Singh, who has been sued for libel by the British Chiropractic Association. They issued a statement entitled "The law has no place in scientific disputes". The amended version added a statement of the belief that "libel laws discriminate against average and low paid people when victims of defamatory comment in the pages of national publications".